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What Are Barbiturates?

Barbiturates are nonselective central nervous system depressants which are primarily used as sedative-hypnotics and also anticonvulsants in sub hypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See ” Drug Abuse and Dependence ” section).

The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions. Buy Nembutal Oral Liquid

Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance that has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.

When Should Nembutal Not Be Taken?

Acute or chronic pain: Caution should be exercised when barbiturates are administered to patients with acute or chronic pain because paradoxical excitement could be induced or important symptoms could be masked. However, the use of barbiturates as sedatives in the postoperative surgical period and as adjuncts to cancer chemotherapy is well established.

Use in pregnancy: Barbiturates can cause fetal damage when administered to a pregnant woman. Retrospective, case-controlled studies have suggested a connection between the maternal consumption of barbiturates and a higher than expected incidence of fetal abnormalities. Following oral or parenteral administration, barbiturates readily cross the placental barrier and are distributed throughout fetal tissues with the highest concentrations found in the placenta, fetal liver, and brain. Fetal blood levels approach maternal blood levels following parenteral administration.
Withdrawal symptoms occur in infants born to mothers who receive barbiturates throughout the last trimester of pregnancy. (See ” Drug Abuse and Dependence ” section). If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

Is Nembutal Useful To The Human Health?

• Typical applications for pentobarbital are sedative, hypnotic for the short term, insomnia, and control of convulsions in emergencies. Abbott Pharmaceutical discontinued the manufacture of its Nembutal brand of Pentobarbital capsules in 1999, largely replaced by the Benzodiazepine family of drugs. Pentobarbital was also widely abused, known on the streets as “yellow jackets”. They were available in 50 and 100 mg. yellow capsules. Pentobarbital in pill form is no longer manufactured.
• It is also used as a veterinary anesthetic agent.
• Pentobarbital also has an application in reducing intracranial pressure in Reye’s syndrome, traumatic brain injury, and induction of coma in cerebral ischemia patients. Pentobarbital-induced coma has been advocated in patients with acute liver failure refractory to mannitol.

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